Synthesis of new coumarin 3-(N-aryl) sulfonamides and their anticancer activity

Natala Srinivasa Reddy; Muralidhar Reddy Mallireddigari; Stephen Cosenza; Kiranmai Gumireddy; Stanley C Bell; E Premkumar Reddy; M V Ramana Reddy

doi:10.1016/j.bmcl.2004.05.016

Synthesis of new coumarin 3-(N-aryl) sulfonamides and their anticancer activity

Bioorg Med Chem Lett. 2004 Aug 2;14(15):4093-7. doi: 10.1016/j.bmcl.2004.05.016.

Authors

Natala Srinivasa Reddy¹, Muralidhar Reddy Mallireddigari, Stephen Cosenza, Kiranmai Gumireddy, Stanley C Bell, E Premkumar Reddy, M V Ramana Reddy

Affiliation

¹ Fels Institute for Cancer Research, Temple University School of Medicine, 3307 North Broad Street, Philadelphia, PA 19140-5101, USA.

PMID: 15225733
DOI: 10.1016/j.bmcl.2004.05.016

Abstract

Synthesis of coumarin 3-(N-aryl) sulfonamides was accomplished either by Knoevenagel condensation of anilinosulfonylacetic acids with suitable salicylaldehydes or by the reaction of methyl anilinosulfonylacetates with substituted salicylaldehydes in presence of a catalytic amount of a base. All the compounds tested for antiproliferative activity in different cancer cell lines have shown GI(50) values less than 100 microM.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents / chemical synthesis*
Antineoplastic Agents / chemistry
Antineoplastic Agents / toxicity
Cell Line, Tumor
Cell Survival / drug effects*
Coumarins / chemical synthesis
Coumarins / toxicity
Humans
K562 Cells
Molecular Conformation
Molecular Structure
Sulfonamides / chemical synthesis*
Sulfonamides / chemistry
Sulfonamides / toxicity*

Substances

Antineoplastic Agents
Coumarins
Sulfonamides