Synthesis of omega-hydroxy ketones from omega-benzyloxy Weinreb amides by using a chemoselective nucleophilic addition/Birch reduction process

Catherine Taillier; Véronique Bellosta; Christophe Meyer; Janine Cossy

doi:10.1021/ol049434f

Synthesis of omega-hydroxy ketones from omega-benzyloxy Weinreb amides by using a chemoselective nucleophilic addition/Birch reduction process

Org Lett. 2004 Jun 24;6(13):2145-7. doi: 10.1021/ol049434f.

Authors

Catherine Taillier¹, Véronique Bellosta, Christophe Meyer, Janine Cossy

Affiliation

¹ Laboratoire de Chimie Organique, associé au CNRS, 10 rue Vauquelin, 75231 Paris Cedex 05, France.

PMID: 15200306
DOI: 10.1021/ol049434f

Abstract

[reaction: see text] A chemoselective nucleophilic addition/Birch reduction process applied to omega-benzyloxy Weinreb amides led to omega-hydroxy ketones in good yields.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amides / chemistry*
Ketones / chemical synthesis*
Magnesium / chemistry*
Organometallic Compounds / chemistry*
Oxidation-Reduction

Substances

Amides
Ketones
Organometallic Compounds
Magnesium