Stiff person syndrome does not always occur with maternal passive transfer of GAD65 antibodies

Neurology. 2004 Jun 8;62(11):2101-2. doi: 10.1212/01.wnl.0000127446.61806.2f.

Abstract

The authors report the presence of high titer antibodies to glutamic acid decarboxylase (anti-GAD65) until age 24 months in two asymptomatic newborns of a woman with stiff-person syndrome (SPS). No signs of SPS were detectable in the two children at ages 6 and 8 years. This observation indicates that other cofactors are involved in the pathogenesis of SPS.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antibody Specificity
  • Autoantibodies / blood
  • Autoantibodies / immunology
  • Autoantigens / immunology*
  • Female
  • Follow-Up Studies
  • Glutamate Decarboxylase / immunology*
  • Humans
  • Immunity, Maternally-Acquired*
  • Infant, Newborn
  • Isoantibodies / blood*
  • Isoantibodies / immunology
  • Isoenzymes / immunology*
  • Pregnancy
  • Pregnancy Complications / immunology*
  • Stiff-Person Syndrome / immunology*
  • Time Factors

Substances

  • Autoantibodies
  • Autoantigens
  • Isoantibodies
  • Isoenzymes
  • Glutamate Decarboxylase
  • glutamate decarboxylase 2