Children in Spain are considered as being a population group with few health problems and needs therefore making it almost invisible in research and services' planning. Generally, it is not taken into account that this is a development period with very high vulnerability to physical and psychosocial risks whereas there is a positive response to protective factors. This article covers some data and thoughts on their health problems that are improving (mortality, cancer), those that persist or worsen (environmental quality, abuse, mental health, obesity, disabilities and lifestyles) and new challenges relating to quality of life and gender and social class equity. Responses provided by the health services are reviewed, as are environmental policies and health promotion and specific care is proposed for boys' and girls' health from a children's human rights-focused perspective.