Nodular lymphocyte predominant Hodgkin lymphoma is reported in 2 siblings with onset at the age of 47 in a woman of Indian ethnic origin and at the age of 52 in her younger brother. Although some cases of familial Hodgkin lymphoma can be related to inherited characteristics and others to Epstein-Barr virus infection, this is not so for familial nodular lymphocyte predominant Hodgkin lymphoma for which the aetiology and reason for the familial occurrence remain unknown.