Cathepsin K inhibitor-polymer conjugates: potential drugs for the treatment of osteoporosis and rheumatoid arthritis

Int J Pharm. 2004 Jun 11;277(1-2):73-9. doi: 10.1016/j.ijpharm.2003.03.003.

Abstract

The role of the newly discovered cysteine protease, cathepsin K, in osteoporosis and rheumatoid arthritis is reviewed. The current development of cathepsin K inhibitors and their targeted delivery using synthetic polymer carriers are discussed. Future challenges and possible strategies to improve these delivery systems are addressed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Arthritis, Rheumatoid / drug therapy*
  • Cathepsin K
  • Cathepsins / antagonists & inhibitors*
  • Cathepsins / metabolism
  • Cysteine Proteinase Inhibitors / chemistry*
  • Cysteine Proteinase Inhibitors / therapeutic use*
  • Humans
  • Osteoporosis / drug therapy*
  • Polymers / chemistry
  • Polymers / therapeutic use

Substances

  • Cysteine Proteinase Inhibitors
  • Polymers
  • Cathepsins
  • CTSK protein, human
  • Cathepsin K