Drug and gene delivery and enhancement of thrombolysis using ultrasound and microbubbles

Jeane Mike Tsutsui; Paul A Grayburn; Feng Xie; Thomas R Porter

doi:10.1016/j.ccl.2004.02.009

Drug and gene delivery and enhancement of thrombolysis using ultrasound and microbubbles

Cardiol Clin. 2004 May;22(2):299-312, vii. doi: 10.1016/j.ccl.2004.02.009.

Authors

Jeane Mike Tsutsui¹, Paul A Grayburn, Feng Xie, Thomas R Porter

Affiliation

¹ Section of Cardiology, Department of Internal Medicine, University of Nebraska Medical Center, 600 South 42nd Street, Omaha, NE 68198, USA.

PMID: 15158941
DOI: 10.1016/j.ccl.2004.02.009

Abstract

This article reviews some important characteristics of microbubbles that give them therapeutic properties. It discusses the use of microbubbles and ultrasound for targeted delivery of adenovirus and nonviral vectors to myocytes and endothelial cells and for the dissolution of thrombus or potentiation of fibrinolytic agents for acutely thrombosed vessels. Potential applications, such as induction of angiogenesis, inhibition of neointimal hyperplasia, and in the setting of acute myocardial infarction and ischemic stroke,are discussed briefly.

Publication types

Review

MeSH terms

Cardiovascular Agents / administration & dosage*
Drug Carriers
Drug Delivery Systems / methods*
Genetic Therapy / methods*
Humans
Microbubbles*
Thrombolytic Therapy / methods*
Ultrasonic Therapy*

Substances

Cardiovascular Agents
Drug Carriers