In the paediatric cardiac catheterization laboratory the reduction of the radiation dose of diagnostic and interventional procedures is of high priority. Therefore, we performed an experimental study for optimizing the automatic exposure control (AEC) for cardiac angiography. With a Philips Integris BH 5000 system, six AEC programs were configured to acquire X-ray images of 8 cm to 18.5 cm thick PMMA phantoms at tube voltages between 50 kV and 90 kV, with 0.2 mm or 0.4 mm Cu filters and with or without an anti-scatter grid. At constant detector dose, entrance dose (ED) and image quality were evaluated as functions of the voltage. Changes in image quality were determined by the differential signal-to-noise ratio measured within regions of low (SNRb) and high (SNRd) attenuation. At equal voltages, ED saving was approximately 29% with the 0.4 mm Cu beam filtering as compared with 0.2 mm Cu, largely independent of object thickness. SNRb and SNRd were only dependent on the voltage. While SNRb was high at low voltages, SNRd showed a maximum at approximately 79 kV. Using a grid, ED increased with increasing object thickness by a factor of 1.9 to 3.5. At equal voltages, the grid led to significant image improvements, with SNRb and SNRd increasing by 27% and 11%, respectively. SNRb and SNRd are useful descriptors of the image quality in cardiac angiography. Highest image quality was found with tube voltages between 55 kV and 77 kV, independently of object thickness. To minimize dose, the thickness of the copper filter should be chosen to be as large as possible provided the tube's power limit allows keeping the voltage below the upper limit. In view of the substantial image improvement, the use of a grid is recommended for all patients, even for newborns.