Poly(N-(2-hydroxypropyl) methacrylamide mono/di lactate): a new class of biodegradable polymers with tuneable thermosensitivity

Osamu Soga; Cornelus F van Nostrum; Wim E Hennink

doi:10.1021/bm049955q

Poly(N-(2-hydroxypropyl) methacrylamide mono/di lactate): a new class of biodegradable polymers with tuneable thermosensitivity

Biomacromolecules. 2004 May-Jun;5(3):818-21. doi: 10.1021/bm049955q.

Authors

Osamu Soga¹, Cornelus F van Nostrum, Wim E Hennink

Affiliation

¹ Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS), Faculty of Pharmaceutical Sciences, Utrecht University, PO Box 80082, 3508 TB, Utrecht, The Netherlands.

PMID: 15132666
DOI: 10.1021/bm049955q

Abstract

A novel class of thermosensitive and biodegradable polymers, poly(N-(2-hydroxypropyl) methacrylamide mono/di lactate) (poly(HPMAm-mono/di lactate)), was synthesized. The cloud points (CP) of poly(HPMAm-monolactate) and poly(HPMAm-dilactate) in water were 65 and 13 degrees C, respectively. The lower CP for poly(HPMAm-dilactate) is likely due the greater hydrophobicity of the dilactate side group over the monolactate side group. The CP of poly(HPMAm-monolactate-co-HPMAm-dilactate) increased linearly with mol % of HPMA-monolactate, which demonstrates that the CP is tuneable by the copolymer composition.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Biodegradation, Environmental*
Lactates / chemistry*
Polymethacrylic Acids / chemistry*
Scattering, Radiation
Temperature

Substances

Lactates
Polymethacrylic Acids
Duxon