Abstract
Present study demonstrated that the ethanolic extracts of propolis containing higher concentrations of flavonoids suppressed 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced aryl hydrocarbon receptor transformation in a dose-dependent manner. The IC(50) values of propolis group 3 and group 12 were 1.2 and 3.6 microg/ml, respectively, indicating that propolis showed stronger antagonistic effects as compared with vegetable extracts.
MeSH terms
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Animals
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Dose-Response Relationship, Drug
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Ethanol / chemistry*
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Flavonoids / chemistry
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Flavonoids / pharmacology
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Fruit / chemistry
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Gene Expression Regulation / drug effects
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Inhibitory Concentration 50
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Plant Extracts / chemistry
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Plant Extracts / pharmacology
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Polychlorinated Dibenzodioxins / antagonists & inhibitors*
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Polychlorinated Dibenzodioxins / pharmacology*
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Propolis / chemistry*
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Propolis / pharmacology*
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Rats
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Receptors, Aryl Hydrocarbon / metabolism*
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Suppression, Genetic / genetics
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Vegetables / chemistry
Substances
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Flavonoids
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Plant Extracts
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Polychlorinated Dibenzodioxins
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Receptors, Aryl Hydrocarbon
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Ethanol
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Propolis