Abstract
This year marks the 25-year anniversary of the discovery by Nishizuka and co-workers that diacylglycerol activates the ubiquitous signal transducer protein kinase C. This discovery placed the lipid second messenger-protein kinase C signaling pathway center stage alongside the cAMP-protein kinase A pathway, which was already established as a fundamental mechanism for transducing extracellular signals.
Publication types
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Diglycerides / pharmacology*
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Enzyme Activation / drug effects
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Humans
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Protein Kinase C* / drug effects
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Protein Kinase C* / metabolism
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Protein Kinase C* / physiology
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Research / trends
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Second Messenger Systems / drug effects
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Second Messenger Systems / physiology*
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Signal Transduction / physiology*
Substances
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Diglycerides
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Protein Kinase C