Cell biological basis for combination radiotherapy using heavy-ion beams and high-energy X-rays

Yusuke Demizu; Kazufumi Kagawa; Yasuo Ejima; Hideki Nishimura; Ryohei Sasaki; Toshinori Soejima; Toshihiro Yanou; Masakazu Shimizu; Yoshiya Furusawa; Yoshio Hishikawa; Kazuro Sugimura

doi:10.1016/j.radonc.2004.03.008

Cell biological basis for combination radiotherapy using heavy-ion beams and high-energy X-rays

Radiother Oncol. 2004 May;71(2):207-11. doi: 10.1016/j.radonc.2004.03.008.

Authors

Yusuke Demizu¹, Kazufumi Kagawa, Yasuo Ejima, Hideki Nishimura, Ryohei Sasaki, Toshinori Soejima, Toshihiro Yanou, Masakazu Shimizu, Yoshiya Furusawa, Yoshio Hishikawa, Kazuro Sugimura

Affiliation

¹ Division of Radiology, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe, Hyogo 650-0017, Japan.

PMID: 15110455
DOI: 10.1016/j.radonc.2004.03.008

Abstract

We investigated the biological effect of combining carbon-beam and X-ray in vitro. The results showed that when we employed Gray equivalent as the indication of therapeutic dose, the effects could be explained with simple additive way in the treatment plan. This fact provides important information about the combined therapy of carbon-beam and X-ray.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Apoptosis / radiation effects*
Carbon*
Cell Line, Tumor
Cell Survival / radiation effects
Cells, Cultured / radiation effects
Combined Modality Therapy
Dose-Response Relationship, Radiation
Humans
Linear Energy Transfer / radiation effects*
Radiation Dosage
Radiotherapy, High-Energy / methods*
Reference Values
Relative Biological Effectiveness
Salivary Gland Neoplasms / pathology
Sensitivity and Specificity

Substances

Carbon