The special structure and function of troponin I in regulation of cardiac contraction and relaxation

Adv Exp Med Biol. 2003:538:389-401; discussion 401-2. doi: 10.1007/978-1-4419-9029-7_36.

Abstract

In this chapter I review evidence for a pivotal role of the sarcomeric thin filament protein, troponin I, in cardiac muscle activation and its modulation by covalent modifications, sarcomere length, and intracellular pH. This evidence demonstrates that the cardiac variant of troponin I (cTnI), which is the only isoform expressed in the adult myocardium, has unique structure and function that are specialized for extrinsic and intrinsic control of cardiac contraction and relaxation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Acidosis
  • Actin Cytoskeleton / chemistry
  • Animals
  • Cyclic AMP-Dependent Protein Kinases / metabolism
  • Dogs
  • Humans
  • Hydrogen-Ion Concentration
  • Mice
  • Models, Molecular
  • Muscle Contraction*
  • Myocardium / cytology
  • Myocardium / metabolism
  • Protein Isoforms
  • Protein Kinase C / metabolism
  • Rats
  • Sarcomeres / metabolism
  • Signal Transduction
  • Troponin I / chemistry*

Substances

  • Protein Isoforms
  • Troponin I
  • Cyclic AMP-Dependent Protein Kinases
  • Protein Kinase C