Abstract
We present a case of a 32-year-old male survivor of two myocardial infarctions, without any classic risk factor of atherosclerosis. Laboratory and genetic diagnostic tests revealed primary antiphospholipid syndrome, mutation in blood coagulation factor V (Leiden) and mild hyperhomocysteinemia, which could be predisposing factors for coronary artery occlusions and should especially be considered in a young patient without apparent cardiovascular risk factors. Additional anticoagulation and substitutional treatment of the folic acid, vitamin B6 and B12 are effective and the continues to do well at home 3 years after discharge.
Publication types
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Case Reports
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English Abstract
MeSH terms
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Activated Protein C Resistance / complications
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Adult
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Antiphospholipid Syndrome / complications*
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Antiphospholipid Syndrome / diagnosis*
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Antiphospholipid Syndrome / drug therapy
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Factor V / genetics*
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Folic Acid / administration & dosage
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Hematinics / administration & dosage
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Humans
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Hyperhomocysteinemia / complications*
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Hyperhomocysteinemia / diagnosis*
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Male
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Myocardial Infarction / drug therapy
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Myocardial Infarction / etiology*
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Myocardial Infarction / genetics
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Point Mutation*
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Time Factors
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Treatment Outcome
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Vitamin B 12 / administration & dosage
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Vitamin B 6 / administration & dosage
Substances
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Hematinics
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Vitamin B 6
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Factor V
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Folic Acid
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Vitamin B 12