[Myocardial infarction as an initial symptom of antiphospholipid syndrome, factor V Leiden mutation, and hyperhomocysteinemia]

Pol Arch Med Wewn. 2004 Jan;111(1):63-7.
[Article in Polish]

Abstract

We present a case of a 32-year-old male survivor of two myocardial infarctions, without any classic risk factor of atherosclerosis. Laboratory and genetic diagnostic tests revealed primary antiphospholipid syndrome, mutation in blood coagulation factor V (Leiden) and mild hyperhomocysteinemia, which could be predisposing factors for coronary artery occlusions and should especially be considered in a young patient without apparent cardiovascular risk factors. Additional anticoagulation and substitutional treatment of the folic acid, vitamin B6 and B12 are effective and the continues to do well at home 3 years after discharge.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Activated Protein C Resistance / complications
  • Adult
  • Antiphospholipid Syndrome / complications*
  • Antiphospholipid Syndrome / diagnosis*
  • Antiphospholipid Syndrome / drug therapy
  • Factor V / genetics*
  • Folic Acid / administration & dosage
  • Hematinics / administration & dosage
  • Humans
  • Hyperhomocysteinemia / complications*
  • Hyperhomocysteinemia / diagnosis*
  • Male
  • Myocardial Infarction / drug therapy
  • Myocardial Infarction / etiology*
  • Myocardial Infarction / genetics
  • Point Mutation*
  • Time Factors
  • Treatment Outcome
  • Vitamin B 12 / administration & dosage
  • Vitamin B 6 / administration & dosage

Substances

  • Hematinics
  • Vitamin B 6
  • Factor V
  • Folic Acid
  • Vitamin B 12