OBJECTIVE: To compare the cutting ability of five handle endodontic instruments. METHODS: The speciments weight loss following serial preparation of artificial root canal were measured with electronic analysis balance. RESULTS: The greatest cutting ability occurred with H file,then with K-flex file,Unifile,K file and K reamer. CONCLUSION: The cutting ability of endodontic instrument is influenced by several factors,such as metallurgical properties,cross-sectional configuration of shaft,flute design and tip design.