Abstract
An 8-week-old female infant presented with a history of active varicella complicated by Escherichia coli sepsis, oral thrush, hypoalbuminemia, intermittent fevers, diarrhea and feeding intolerance. Rhesus monkey kidney cells inoculated with cerebrospinal fluid revealed reovirus-like particles by electron microscopy. Virus neutralization and RNA-gel electrophoresis studies identified the isolated pathogen as reovirus serotype 2. This report represents one of only a few to isolate reovirus from the central nervous system in humans.
Publication types
-
Case Reports
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Combined Modality Therapy
-
Disease Progression
-
Fatal Outcome
-
Female
-
Humans
-
Immunologic Deficiency Syndromes / complications
-
Immunologic Deficiency Syndromes / diagnosis*
-
Immunologic Deficiency Syndromes / therapy
-
Infant
-
Meningitis, Viral / cerebrospinal fluid*
-
Meningitis, Viral / complications
-
Meningitis, Viral / diagnosis*
-
Meningitis, Viral / therapy
-
Orthoreovirus, Mammalian / isolation & purification*
-
Reoviridae Infections / complications
-
Reoviridae Infections / diagnosis*
-
Reoviridae Infections / therapy
-
Risk Assessment
-
Severity of Illness Index