Azithromycin as an alternative to nalidixic acid in the therapy of childhood shigellosis

Pediatr Infect Dis J. 2004 Apr;23(4):367-8. doi: 10.1097/00006454-200404000-00022.

Abstract

In an outbreak of shigellosis in a kibbutz in Northeastern Israel, oral nalidixic acid failed clinically in 35% and microbiologically in 28.4% of 14 children as compared with no clinical and microbiologic failure in 25 children who were treated with oral azithromycin (P < 0.01 and 0.012, respectively). Thus azithromycin could be a suitable alternative to nalidixic acid.

Publication types

  • Comparative Study

MeSH terms

  • Administration, Oral
  • Adolescent
  • Azithromycin / administration & dosage*
  • Child
  • Child, Preschool
  • Cohort Studies
  • Disease Outbreaks*
  • Dose-Response Relationship, Drug
  • Drug Administration Schedule
  • Dysentery, Bacillary / diagnosis
  • Dysentery, Bacillary / drug therapy*
  • Dysentery, Bacillary / epidemiology*
  • Female
  • Follow-Up Studies
  • Humans
  • Infant
  • Israel / epidemiology
  • Male
  • Nalidixic Acid / administration & dosage*
  • Probability
  • Sensitivity and Specificity
  • Severity of Illness Index
  • Treatment Outcome

Substances

  • Nalidixic Acid
  • Azithromycin