Evaluation of rapid assay for detection of Streptococcus pneumoniae urinary antigen among infants and young children with possible invasive pneumococcal disease

Pediatr Infect Dis J. 2004 Apr;23(4):365-7. doi: 10.1097/00006454-200404000-00021.

Abstract

The usefulness of the rapid assay for detection of Streptococcus pneumoniae urinary antigen was evaluated in 155 children ages 1 to 60 months with suspected invasive pneumococcal disease and 200 healthy controls. Although the assay was highly sensitive in the children with invasive pneumococcal disease, it should be interpreted with caution in young patients because a positive urine test result may simply be the result of nasopharyngeal colonization.

Publication types

  • Evaluation Study

MeSH terms

  • Antigens, Bacterial / analysis*
  • Antigens, Bacterial / urine
  • Bacteremia / diagnosis*
  • Bacteremia / epidemiology
  • Case-Control Studies
  • Child, Preschool
  • Female
  • Humans
  • Immunoassay / methods*
  • Infant
  • Italy / epidemiology
  • Male
  • Pneumococcal Infections / diagnosis*
  • Pneumococcal Infections / epidemiology
  • Predictive Value of Tests
  • Probability
  • Prospective Studies
  • Reference Values
  • Sensitivity and Specificity
  • Severity of Illness Index
  • Statistics, Nonparametric
  • Streptococcus pneumoniae / isolation & purification*
  • Urinalysis

Substances

  • Antigens, Bacterial