Symmetrical dinuclear complexes with high DNA affinity based on [Ru(dpq)2(phen)]2+

Chem Commun (Camb). 2004 Apr 21:(8):1018-9. doi: 10.1039/b316917k. Epub 2004 Mar 23.

Abstract

Symmetrical homometallic dinuclear complexes of the type [(Ru(dpq)2)2(phen-SOS-phen)]4+, with a flexible 2-mercaptoethyl ether linker joining the two [Ru(dpq)2(phen)]2+-based sub-units, have DNA dissociation constants (Kd) in the nM range.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Base Sequence
  • Binding Sites
  • DNA / chemistry*
  • DNA Probes*
  • Dimerization
  • Intercalating Agents / chemistry*
  • Ligands
  • Mercaptoethanol / chemistry*
  • Organometallic Compounds / chemistry*
  • Phenanthrolines / chemistry*
  • Pyridines / chemistry
  • Pyrimidines / chemistry
  • Quinoxalines / chemistry*
  • Ruthenium / chemistry*
  • Thermodynamics

Substances

  • DNA Probes
  • Intercalating Agents
  • Ligands
  • Organometallic Compounds
  • Phenanthrolines
  • Pyridines
  • Pyrimidines
  • Quinoxalines
  • Mercaptoethanol
  • Ruthenium
  • DNA