[Study on effect of flavonoids from oil-removed seeds of Hippophae rhamnoides on inducing apoptosis of human hepatoma cell]

Bin Sun; Ping Zhang; Weijing Qu; Xiaoling Zhang; Xiuyuan Zhuang; Huangjian Yang

[Study on effect of flavonoids from oil-removed seeds of Hippophae rhamnoides on inducing apoptosis of human hepatoma cell]

Zhong Yao Cai. 2003 Dec;26(12):875-7.

[Article in Chinese]

Authors

Bin Sun¹, Ping Zhang, Weijing Qu, Xiaoling Zhang, Xiuyuan Zhuang, Huangjian Yang

Affiliation

¹ Life Science School of East China Normal University, Shanghai 200062.

PMID: 15058208

Abstract

Objective: To investigate the inhibitory and apoptosis-inducing effects of flavonoids from oil-removed seeds of Hippophae rhamnoides (FSH) on liver cancer cell line BEL-7402.

Methods: SRB, Wright staining, electron microscope and flow cytometry are used to study the effects of STT on BEL-7402 cell line.

Results: FSH has potent inhibitive effect on BEL-7402 cell line in a concentration-dependent manner. BEL-7402 cells exhibit typical morphological alteration of apoptosis when sub-Gl peak can be seen.

Conclusion: FSH exerts its inhibitive effect on BEL-7402 cells by inducing apoptosis.

Publication types

English Abstract
Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents, Phytogenic / pharmacology
Apoptosis / drug effects*
Carcinoma, Hepatocellular / pathology*
Drugs, Chinese Herbal / pharmacology*
Flavonoids / pharmacology*
Hippophae* / chemistry
Humans
Liver Neoplasms / pathology*
Plants, Medicinal / chemistry
Seeds / chemistry
Tumor Cells, Cultured

Substances

Antineoplastic Agents, Phytogenic
Drugs, Chinese Herbal
Flavonoids