[Intractable diarrhoea revealing a neuroblastoma hypersecreting the vasoactive intestinal peptide]

B Bourgois; F Boman; B Nelken; M Bonnevalle; D Turck

doi:10.1016/j.arcped.2004.01.015

[Intractable diarrhoea revealing a neuroblastoma hypersecreting the vasoactive intestinal peptide]

Arch Pediatr. 2004 Apr;11(4):340-3. doi: 10.1016/j.arcped.2004.01.015.

[Article in French]

Authors

B Bourgois¹, F Boman, B Nelken, M Bonnevalle, D Turck

Affiliation

¹ Clinique de pédiatrie, hôpital Jeanne-de-Flandre, 2, avenue Oscar-Lambret, 59037 Lille, France.

PMID: 15051093
DOI: 10.1016/j.arcped.2004.01.015

Abstract

In children, the watery diarrhoea-hypokalemia-achlorhydria (WDHA) syndrome is uncommon and usually due to a neuroblastic tumour hypersecreting the vasoactive intestinal peptide (VIP). We report a case of WDHA syndrome secondary to hypersecretion of VIP that revealed a neuroblastoma in a 13-month-old girl. A secretory diarrhoea, characterised by the persistence of diarrhoea despite the cessation of oral feeding, led to the search of a neuroblastic tumour in the patient. The serum concentration of VIP decreased to normal values soon after the surgical excision of the tumour.

Publication types

Case Reports
English Abstract

MeSH terms

Diagnosis, Differential
Diarrhea / etiology*
Female
Humans
Infant
Neuroblastoma / complications*
Neuroblastoma / diagnosis
Vasoactive Intestinal Peptide / analysis*
Vasoactive Intestinal Peptide / pharmacology
Vipoma / complications*
Vipoma / diagnosis

Substances

Vasoactive Intestinal Peptide