Immune responses to Puumala virus infection and the pathogenesis of nephropathia epidemica

Masanori Terajima; Olli Vapalahti; Heather L Van Epps; Antti Vaheri; Francis A Ennis

doi:10.1016/j.micinf.2003.10.017

Immune responses to Puumala virus infection and the pathogenesis of nephropathia epidemica

Microbes Infect. 2004 Feb;6(2):238-45. doi: 10.1016/j.micinf.2003.10.017.

Authors

Masanori Terajima¹, Olli Vapalahti, Heather L Van Epps, Antti Vaheri, Francis A Ennis

Affiliation

¹ Center for Infectious Disease and Vaccine Research, S5-326 University of Massachusetts Medical School, Worcester, 01655, USA.

PMID: 15049335
DOI: 10.1016/j.micinf.2003.10.017

Abstract

Puumala virus, causative agent of a mild form of hemorrhagic fever with renal syndrome, also known as nephropathia epidemica, induces long-lasting humoral and cellular immunity in patients. The virus itself is not cytopathic, and the immune responses to the virus may be involved in teh pathogenesis of the disease.

Publication types

Research Support, U.S. Gov't, P.H.S.
Review

MeSH terms

Hantavirus Infections / epidemiology
Hantavirus Infections / immunology
Hemorrhagic Fever with Renal Syndrome / immunology*
Hemorrhagic Fever with Renal Syndrome / pathology
Hemorrhagic Fever with Renal Syndrome / physiopathology
Hemorrhagic Fever with Renal Syndrome / virology
Humans
Puumala virus*

Grants and funding

P01 AI-39780/AI/NIAID NIH HHS/United States