Clonal relatedness of erythromycin-resistant Streptococcus pyogenes isolates in Germany

Antimicrob Agents Chemother. 2004 Apr;48(4):1369-73. doi: 10.1128/AAC.48.4.1369-1373.2004.

Abstract

In a nationwide study in Germany, a total of 381 Streptococcus pyogenes were collected. Erythromycin A-resistant strains were characterized for the underlying resistance genotype, showing 55.6% had the efflux type mef(A), 31.5% had erm(A), and 13.0% had erm(B). A total of 23 different multilocus sequence types were observed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Bacterial Proteins / genetics
  • Drug Resistance, Bacterial
  • Erythromycin / pharmacology*
  • Genes, Bacterial / genetics
  • Genotype
  • Germany / epidemiology
  • Humans
  • Membrane Proteins / genetics
  • Methyltransferases / genetics
  • Reverse Transcriptase Polymerase Chain Reaction
  • Streptococcal Infections / epidemiology
  • Streptococcal Infections / microbiology
  • Streptococcus pyogenes / drug effects*
  • Streptococcus pyogenes / genetics*

Substances

  • Anti-Bacterial Agents
  • Bacterial Proteins
  • MefA protein, Streptococcus
  • Membrane Proteins
  • Erythromycin
  • Methyltransferases
  • ErmA protein, Bacteria