Discorhabdins I and L, cytotoxic alkaloids from the sponge Latrunculia brevis

J Nat Prod. 2004 Mar;67(3):463-5. doi: 10.1021/np0303761.

Abstract

Two cytotoxic alkaloids, discorhabdins L (1) and I (2), were isolated from Latrunculia brevis and their structures assigned on the basis of detailed spectroscopic analysis and comparison with the known metabolites discorhabdins R (5), D (6), and B (4). Compounds 1 and 2 showed strong in vitro cytotoxicity against a panel of 14 tumor cell lines.

Publication types

  • Comparative Study

MeSH terms

  • Alkaloids / chemistry
  • Alkaloids / isolation & purification*
  • Alkaloids / pharmacology
  • Animals
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / isolation & purification*
  • Antineoplastic Agents / pharmacology
  • Cell Line, Tumor
  • Drug Screening Assays, Antitumor
  • Heterocyclic Compounds, 4 or More Rings / chemistry
  • Heterocyclic Compounds, 4 or More Rings / isolation & purification*
  • Heterocyclic Compounds, 4 or More Rings / pharmacology
  • Humans
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Oceans and Seas
  • Porifera / chemistry*
  • Quinones / chemistry
  • Quinones / isolation & purification*
  • Quinones / pharmacology

Substances

  • Alkaloids
  • Antineoplastic Agents
  • Heterocyclic Compounds, 4 or More Rings
  • Quinones
  • discorhabdin I
  • discorhabdin L