We present a case of postinfarction ventricular septal rupture (VSR) who underwent successful repair using a modified infarction exclusion technique. In our procedure a heterologous pericardial patch is sutured to healthy endocardium in the free wall and septum all around the infarcted area. Interrupted circular mattress sutures were placed through the ventricular wall in such a way as to exclude the VSR and the infarcted muscle of the left ventricle. We describe herein a novel procedure for repairing postinfarction VSR, by the transmural infarction exclusion technique.