Scale-up of erythritol production by an osmophilic mutant of Candida magnoliae

Biotechnol Lett. 2003 Dec;25(24):2103-5. doi: 10.1023/b:bile.0000007076.64338.ce.

Abstract

Erythritol production by an osmophilic mutant of Candida magnoliae was performed in fermentations of up 50 l to develop an optimized commercial process. By simultaneous feeding glucose and yeast extract, erythritol productivity of 1.2 g l(-1) h(-1) was reached giving 200 g erythritol l(-1) with a yield of 0.43 g g(-1).

Publication types

  • Evaluation Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bioreactors / microbiology
  • Candida / cytology
  • Candida / genetics
  • Candida / growth & development*
  • Candida / metabolism*
  • Cell Culture Techniques / methods*
  • Cell Division / physiology
  • Erythritol / biosynthesis*
  • Erythritol / genetics
  • Glucose / metabolism*
  • Mutation
  • Osmosis / physiology
  • Pilot Projects
  • Quality Control

Substances

  • Glucose
  • Erythritol