Abstract
The expense of PCR testing limits diagnosis of HIV infection in infancy in low resource settings. The ultrasensitive p24 antigen assay has been proposed as an accurate substitute; however, its ability to detect different HIV viral subtypes remains to be determined. A sensitivity of 98.1% and specificity of 98.7% was obtained testing 203 samples from 24 HIV-infected and 66 uninfected infants born to HIV subtype C-infected women.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antigens, Viral / analysis
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Clinical Laboratory Techniques / economics*
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Cohort Studies
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Cost Savings
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Developing Countries
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Female
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HIV Core Protein p24 / analysis*
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HIV Core Protein p24 / economics
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HIV Infections / diagnosis*
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HIV Infections / economics*
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HIV-1 / isolation & purification*
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Humans
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Infant
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Infant, Newborn
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Infectious Disease Transmission, Vertical
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Male
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Pregnancy
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Sampling Studies
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Sensitivity and Specificity
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Socioeconomic Factors
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South Africa
Substances
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Antigens, Viral
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HIV Core Protein p24