Generation of mutant mice lacking surface expression of CD4 or CD8 gene targeting

Adv Exp Med Biol. 1992:323:73-7. doi: 10.1007/978-1-4615-3396-2_10.

Abstract

With the use of homologous recombination in embryonic stem cells, two new strains of mice lacking surface CD4 or CD8 expression have been generated. It is hoped that they will be useful mouse strains for the study of autoimmune diseases, tissue transplantation rejections and tumour rejections.

Publication types

  • Review

MeSH terms

  • Animals
  • Antigens, Ly / biosynthesis
  • Antigens, Ly / genetics*
  • Autoimmune Diseases
  • CD4 Antigens / biosynthesis
  • CD4 Antigens / genetics*
  • CD8 Antigens / biosynthesis
  • CD8 Antigens / genetics*
  • Disease Models, Animal*
  • Exons
  • Gene Expression Regulation
  • Immunity, Cellular
  • Mice / embryology
  • Mice, Mutant Strains / genetics
  • Mice, Mutant Strains / immunology*
  • Mutagenesis, Insertional
  • Recombination, Genetic
  • Stem Cells
  • Transplantation Immunology

Substances

  • Antigens, Ly
  • CD4 Antigens
  • CD8 Antigens