Antiphospholipid syndrome in a child with trisomy 21: the relationship between anticardiolipin G antibodies and the von Willebrand factor

G Guariso; A Ruffatti; A Casonato; P Drigo; A Ghirardello; L Zancan

Antiphospholipid syndrome in a child with trisomy 21: the relationship between anticardiolipin G antibodies and the von Willebrand factor

Clin Exp Rheumatol. 1992 Nov-Dec;10(6):613-6.

Authors

G Guariso¹, A Ruffatti, A Casonato, P Drigo, A Ghirardello, L Zancan

Affiliation

¹ Department of Pediatric Clinics, University of Padova, Italy.

PMID: 1483315

Abstract

A young child with trisomy 21 developed severe multiple arterial thromboses in a three-phase clinical course which proved fatal. The episodes were characterized by high levels of both IgG anticardiolipin antibodies and the von Willebrand factor. The data suggest that there is a relationship between these two elements and the clinical events which followed.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Antibodies, Anticardiolipin / analysis*
Antiphospholipid Syndrome / blood
Antiphospholipid Syndrome / complications
Antiphospholipid Syndrome / immunology*
Down Syndrome / blood
Down Syndrome / complications
Down Syndrome / immunology*
Humans
Immunoglobulin G / analysis
Infant
Male
Thrombosis / complications
von Willebrand Factor / analysis*

Substances

Antibodies, Anticardiolipin
Immunoglobulin G
von Willebrand Factor