Effects of resin swelling and substitution on solid phase synthesis

K C Pugh; E J York; J M Stewart

doi:10.1111/j.1399-3011.1992.tb00293.x

Effects of resin swelling and substitution on solid phase synthesis

Int J Pept Protein Res. 1992 Sep-Oct;40(3-4):208-13. doi: 10.1111/j.1399-3011.1992.tb00293.x.

Authors

K C Pugh¹, E J York, J M Stewart

Affiliation

¹ Department of Biochemistry, University of Colorado School of Medicine, Denver.

PMID: 1478778
DOI: 10.1111/j.1399-3011.1992.tb00293.x

Abstract

Resins sold by several companies were examined for swelling, uniformity of beads, and substitution in the case of resins sold with the first amino acid attached. Effects of resin swelling, uniformity, and substitution on the solid phase synthesis of long, structured and/or branched peptides were evaluated.

Publication types

Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

MeSH terms

Amino Acid Sequence
Microspheres
Molecular Sequence Data
Peptides / chemical synthesis*
Protein Structure, Secondary*
Resins, Synthetic / chemistry*

Substances

Peptides
Resins, Synthetic

Grants and funding

GM-31475/GM/NIGMS NIH HHS/United States