Tumor markers. An update approach for their prognostic significance. Part I

In Vivo. 2003 Nov-Dec;17(6):609-18.

Abstract

Identification of prognostic tumor markers is a main strategy for planning treatment and predicting outcome of patients with various malignancies. This article reviews a panel of proliferation markers, hormone receptors, oncogene products and apoptosis regulators that have shown potential as prognostic indicators in common human cancers. At present, steroid receptors and the c-erbB-2 gene are the only tissue-based markers accepted in clinical practice, having an established role in breast cancer prognosis. Other markers e.g., the p53 gene, look promising as prognostic factors in different kinds of cancer.

Publication types

  • Review

MeSH terms

  • Biomarkers, Tumor*
  • Humans
  • Neoplasms / pathology*
  • Neoplasms / physiopathology*
  • Predictive Value of Tests
  • Prognosis

Substances

  • Biomarkers, Tumor