[Synthesis and antiviral activity of ureides and carbamates of betulinic acid and its derivatives]

Bioorg Khim. 2003 Nov-Dec;29(6):655-61. doi: 10.1023/b:rubi.0000008902.36604.97.
[Article in Russian]

Abstract

Ureides and carbamates of betulinic acid and its derivatives were prepared in good yields by interaction of betulinic acid, betulonic acid, and betulonic acid 3-oxime with amines, amino acids, and alcohols. Ureides of betulonic acid containing L-Val and L-Met residues were found to be effective against herpes simplex type 1 virus. The English version of the paper: Russian Journal of Bioorganic Chemistry, 2003, vol. 29, no. 6; see also http://www.maik.ru.

MeSH terms

  • Antiviral Agents / chemical synthesis*
  • Antiviral Agents / pharmacology*
  • Betulinic Acid
  • Carbamates / chemical synthesis
  • Carbamates / pharmacology
  • Magnetic Resonance Spectroscopy
  • Pentacyclic Triterpenes
  • Spectrophotometry, Infrared
  • Triterpenes / chemical synthesis*
  • Triterpenes / pharmacology*

Substances

  • Antiviral Agents
  • Carbamates
  • Pentacyclic Triterpenes
  • Triterpenes
  • Betulinic Acid