Abstract
Three immunizations of mice with recombinant protective antigen (rPA) by transcutaneous immunization (TCI) induced long-term neutralizing antibody titers that were superior to those obtained with aluminum-adsorbed rPA. In addition, rPA alone exhibited adjuvant activity for TCI. Forty-six weeks after completion of TCI, 100% protection was observed against lethal anthrax challenge.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Adjuvants, Immunologic / pharmacology
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Administration, Cutaneous
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Animals
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Anthrax Vaccines / administration & dosage*
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Anthrax Vaccines / immunology
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Antibodies, Bacterial / blood
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Antigens, Bacterial*
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Bacterial Toxins / immunology*
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Bacterial Toxins / pharmacology
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Enterotoxins / pharmacology
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Escherichia coli Proteins*
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Female
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Mice
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Vaccination / methods*
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Vaccines, Synthetic / administration & dosage*
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Vaccines, Synthetic / immunology
Substances
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Adjuvants, Immunologic
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Anthrax Vaccines
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Antibodies, Bacterial
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Antigens, Bacterial
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Bacterial Toxins
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Enterotoxins
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Escherichia coli Proteins
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Vaccines, Synthetic
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anthrax toxin
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heat-labile enterotoxin, E coli