Abstract
Leishmaniases, which are important causes of morbidity and mortality in humans and dogs, are extremely difficult to treat. Antimicrobial peptides are rarely used as alternative treatments for naturally acquired parasitic diseases. Here we report that the acylated synthetic antimicrobial peptide Oct-CA(1-7)M(2-9) is safe and effective for treating naturally acquired canine leishmaniasis.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Infective Agents / adverse effects
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Anti-Infective Agents / therapeutic use*
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Antimicrobial Cationic Peptides / adverse effects
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Antimicrobial Cationic Peptides / therapeutic use*
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Dog Diseases / drug therapy*
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Dog Diseases / parasitology
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Dogs
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Leishmania infantum
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Leishmaniasis, Visceral / drug therapy*
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Leishmaniasis, Visceral / parasitology
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Leishmaniasis, Visceral / veterinary*
Substances
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Anti-Infective Agents
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Antimicrobial Cationic Peptides
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octyl-cecropin(1-7)melittin(2-9)