Colchicine-induced rhabdomyolysis in a patient with chronic heart failure

Acta Cardiol. 2003 Dec;58(6):561-2. doi: 10.2143/AC.58.6.2005322.

Abstract

Gout is a common co-morbidity in patients with chronic heart failure and its treatment is complex. We report the case of a 58-year-old man with chronic severe heart failure who developed rhabdomyolisis after short-term intake of colchicine. Although colchicine is a highly effective therapy for acute gouty arthritis, the dosage should be carefully titrated in patients with chronic heart failure, especially if renal or liver disease are also present.

Publication types

  • Case Reports

MeSH terms

  • Biomarkers / blood
  • Chronic Disease
  • Colchicine / adverse effects*
  • Creatine Kinase / blood
  • Creatinine / blood
  • Gout / drug therapy
  • Gout Suppressants / adverse effects*
  • Heart Failure / drug therapy*
  • Humans
  • Kidney Failure, Chronic / blood
  • Kidney Failure, Chronic / chemically induced
  • Kidney Failure, Chronic / diagnosis
  • Male
  • Middle Aged
  • Rhabdomyolysis / blood
  • Rhabdomyolysis / chemically induced*
  • Rhabdomyolysis / diagnosis

Substances

  • Biomarkers
  • Gout Suppressants
  • Creatinine
  • Creatine Kinase
  • Colchicine