Assessment of tracheal intubation in children after induction with propofol and different doses of remifentanil

Anaesthesia. 2004 Jan;59(1):27-33. doi: 10.1111/j.1365-2044.2004.03524.x.

Abstract

Tracheal intubating conditions were assessed in 112 children after induction of anaesthesia with propofol and remifentanil 1.0, 2.0 or 3.0 micro g.kg-1. Subjects in a control group were given propofol and mivacurium 0.2 mg.kg-1. Haemodynamic and respiratory parameters were recorded. Plasma catecholamine levels were measured in a subgroup of 40 children. Intubating conditions were acceptable in 14/28 (50%), 18/26 (69%) and 22/27 (82%) in those subjects given remifentanil 1.0, 2.0 or 3.0 micro g.kg-1, respectively, and in 27/28 (96%) of the control group. Intubating conditions in subjects given remifentanil 3.0 micro g.kg-1 were better than in those given remifentanil 1.0 micro g.kg-1 (p < 0.05). There were no significant differences in intubating conditions between those given remifentanil 3.0 micro g.kg-1 and the control group. Systolic blood pressure and heart rate increased in response to tracheal intubation in subjects given remifentanil 1.0 micro g.kg-1 and in the control group (p < 0.05). Time to resumption of spontaneous respiration was prolonged in subjects given remifentanil 3.0 micro g.kg-1 (p < 0.001). In conclusion, remifentanil 2 micro g.kg-1 provides acceptable intubating conditions and haemodynamic stability without prolonging the return of spontaneous respiration.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Analgesics, Opioid / administration & dosage*
  • Anesthetics, Intravenous*
  • Blood Pressure / drug effects
  • Child
  • Child, Preschool
  • Dose-Response Relationship, Drug
  • Epinephrine / blood
  • Female
  • Heart Rate / drug effects
  • Humans
  • Intubation, Intratracheal / methods*
  • Laryngoscopy
  • Male
  • Norepinephrine / blood
  • Piperidines / administration & dosage*
  • Propofol*
  • Remifentanil
  • Respiration / drug effects

Substances

  • Analgesics, Opioid
  • Anesthetics, Intravenous
  • Piperidines
  • Remifentanil
  • Norepinephrine
  • Propofol
  • Epinephrine