[Evaluation of different approaches to the treatment of arterial hypertension: combination treatment with low dose perindopril/indapamide versus sequential treatment of stepped-dose treatment]

Abstract

A randomised double-blind comparison of three treatment strategies in 533 patients with mild-to-moderate hypertension over 6-9 months. The low-dose perindopril/indapamide (PER/IND) combination (2 mg and 0.625 mg, respectively) daily resulted in a significantly better blood pressure control and systolic blood pressure decrease. In addition, the low-dose PER/IND combination showed superior efficacy/safety criteria than the sequential strategy of atenolol (50 mg) then losartan (50 mg) then amlodipine (5 mg), and the step-by-step strategy of valsartan (40 mg then 80 mg then 80 mg plus hydrochlorothiazide 12.5 mg).