Abstract
We have investigated transferrin synthesis by human and mouse lymphoid and myeloid cells. It was found that transferrin synthesis is a property of mouse but not human macrophages, whereas in man T lymphocytes synthesised transferrin. Synthesis by mouse macrophages showed a dose-dependent increase in response to gamma-interferon (gamma-IFN), but iron added as ferric nitrilotriacetate had no effect. Macrophage-derived transferrin was found to contain iron already bound to it and was able to support Con A-stimulated mouse lymphocyte proliferation.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Cell Line
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Ferric Compounds / pharmacology
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Humans
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Interferon-gamma / pharmacology*
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Lymphocyte Activation*
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Lymphocytes / immunology
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Macrophages / metabolism*
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Macrophages, Alveolar / metabolism*
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Mice
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Nitrilotriacetic Acid / analogs & derivatives
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Nitrilotriacetic Acid / pharmacology
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T-Lymphocytes / immunology
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T-Lymphocytes / metabolism
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Transferrin / biosynthesis*
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Up-Regulation
Substances
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Ferric Compounds
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Transferrin
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Interferon-gamma
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Nitrilotriacetic Acid
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ferric nitrilotriacetate