A quantitative study of magnetization transfer in MAGIC gels

Phys Med Biol. 2003 Nov 7;48(21):N277-82. doi: 10.1088/0031-9155/48/21/n01.

Abstract

Magnetization transfer (MT) has been measured quantitatively as a function of radiation dose in MAGIC polymer gels. The MT rates between the free and immobile macromolecular proton pools (kmr and kfm), and the ratio of the sizes of these coupled proton pools (Pm/Pf), were measured by analysing the response to an inversion recovery sequence. While pm/pf increases linearly with dose, the fast MT rate kmf also increases with dose, unlike previous measurements in BANG gels. This dependence of kmf on dose suggests there are additional factors that modify spin exchange in MAGIC gels as irradiation occurs.

Publication types

  • Comparative Study
  • Evaluation Study
  • Research Support, U.S. Gov't, P.H.S.
  • Validation Study

MeSH terms

  • Ascorbic Acid / chemistry*
  • Ascorbic Acid / radiation effects*
  • Computer Simulation
  • Copper Sulfate / chemistry*
  • Copper Sulfate / radiation effects*
  • Gelatin / chemistry*
  • Gelatin / radiation effects*
  • Hydroquinones / chemistry*
  • Hydroquinones / radiation effects*
  • Magnetic Resonance Imaging / methods*
  • Magnetics*
  • Materials Testing / methods*
  • Methacrylates / chemistry*
  • Methacrylates / radiation effects*
  • Models, Chemical*
  • Polymers / chemistry*
  • Polymers / radiation effects*
  • Radiation Dosage
  • Radiometry / instrumentation*
  • Radiometry / methods*
  • Reproducibility of Results
  • Sensitivity and Specificity

Substances

  • Hydroquinones
  • MAGIC polymer gel
  • Methacrylates
  • Polymers
  • Gelatin
  • Copper Sulfate
  • Ascorbic Acid