Acetazolamide in hemodialysis patients: a rational use after ocular surgery

Am J Kidney Dis. 1992 Dec;20(6):650-2. doi: 10.1016/s0272-6386(12)70235-4.

Abstract

Acetazolamide is a weak diuretic used to decrease production of aqueous humor in the eye. Hemodialysis patients undergoing ocular surgery may benefit from acetazolamide; however, no pharmacokinetic data are available for this group of patients. We report a patient who received acetazolamide 250 mg every 6 hours after ophthalmic surgery and developed reversible neurological side effects associated with very high plasma concentrations. Using pharmacokinetic analysis, we suggest an alternate administration of acetazolamide for end-stage renal patients.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetazolamide / adverse effects*
  • Acetazolamide / blood
  • Acetazolamide / pharmacokinetics
  • Adult
  • Brain / drug effects*
  • Confusion / chemically induced
  • Diabetes Mellitus, Type 1
  • Diabetic Nephropathies / therapy
  • Female
  • Hallucinations / chemically induced
  • Humans
  • Kidney Failure, Chronic / therapy*
  • Renal Dialysis*
  • Vitreous Hemorrhage / surgery*

Substances

  • Acetazolamide