The interaction of tetrahydroisoquinoline derivatives with antinociceptive action of morphine and oxotremorine in mice

J Neural Transm (Vienna). 2003 Nov;110(11):1205-13. doi: 10.1007/s00702-003-0037-3.

Abstract

To extend our earlier data on synergistic action of tetrahydroisoquinolines and morphine, we have investigated the analgesic effects of 1,2,3,4-tetrahydroisoquinoline (TIQ) and its 1-methyl-(1-MeTIQ) and N-methyl (N-MeTIQ) analogs on analgesia induced by morphine and oxotremorine. 1-MeTIQ and N-MeTIQ induced a moderate, delayed and prolonged analgesic action measured in the tail-flick test in CD-1 mice; 1-MeTIQ and TIQ prolonged the opiate (morphine, 2.5 mg/kg i.p.) analgesia while TIQ and N-TIQ potentiated cholinergic (oxotremorine, 0.02 mg/kg i.p.) analgesia. The involvement of the opioid and noradrenergic systems in this effect is discussed.

MeSH terms

  • Acetylcholine / metabolism
  • Analgesics / pharmacology*
  • Animals
  • Central Nervous System / drug effects
  • Central Nervous System / metabolism
  • Central Nervous System / physiopathology
  • Drug Synergism
  • Male
  • Mice
  • Morphine / pharmacology*
  • Nociceptors / drug effects
  • Nociceptors / physiology
  • Norepinephrine / metabolism
  • Opioid Peptides / metabolism
  • Oxotremorine / pharmacology*
  • Pain / drug therapy*
  • Pain / metabolism
  • Pain / physiopathology
  • Pain Measurement / drug effects
  • Reaction Time / drug effects
  • Reaction Time / physiology
  • Receptors, Adrenergic, alpha-2 / drug effects
  • Receptors, Adrenergic, alpha-2 / metabolism
  • Receptors, Opioid / drug effects
  • Receptors, Opioid / metabolism
  • Tetrahydroisoquinolines / pharmacology*

Substances

  • Analgesics
  • Opioid Peptides
  • Receptors, Adrenergic, alpha-2
  • Receptors, Opioid
  • Tetrahydroisoquinolines
  • 1-methyl-1,2,3,4-tetrahydroisoquinoline
  • 1,2,3,4-tetrahydroisoquinoline
  • Oxotremorine
  • Morphine
  • Acetylcholine
  • Norepinephrine