Abstract
This article reviews the evidence that obsessive compulsive disorder (OCD) and Gilles de la Tourette's syndrome (GTS) are both familial and genetic. Studies are summarized that suggest that (1) some forms of OCD are related to GTS, (2) some forms of OCD are familial and may not be related to GTS, and (3) the patterns of inheritance of GTS and OCD within the same families are consistent with the transmission of an autosomal dominant genetic locus.
Publication types
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Diseases in Twins / genetics
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Diseases in Twins / psychology
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Gene Expression Regulation / physiology
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Genetic Markers / genetics
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Humans
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Obsessive-Compulsive Disorder / diagnosis
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Obsessive-Compulsive Disorder / genetics*
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Obsessive-Compulsive Disorder / psychology
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Risk Factors
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Tourette Syndrome / diagnosis
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Tourette Syndrome / genetics*
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Tourette Syndrome / psychology
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Twins, Dizygotic / genetics
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Twins, Dizygotic / psychology
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Twins, Monozygotic / genetics
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Twins, Monozygotic / psychology