Highly conjugative pMG1-like plasmids carrying Tn1546-like transposons that encode vancomycin resistance in Enterococcus faecium

J Bacteriol. 2003 Dec;185(23):7024-8. doi: 10.1128/JB.185.23.7024-7028.2003.

Abstract

A total of 12 VanA-type vancomycin-resistant enterococci, consisting of 10 Enterococcus faecium isolates and two Enterococcus avium isolates, were examined in detail. The vancomycin resistance conjugative plasmids pHTalpha (65.9 kbp), pHTbeta (63.7 kbp), and pHTgamma (66.5 kbp) were isolated from each of three different E. faecium strains. The plasmids transferred highly efficiently between enterococcus strains during broth mating and were homologous with pMG1 (Gm(r); 65.1 kb).

MeSH terms

  • Anti-Bacterial Agents / pharmacology
  • DNA Transposable Elements
  • Drug Resistance, Bacterial / genetics*
  • Enterococcus faecium / drug effects
  • Enterococcus faecium / genetics*
  • Humans
  • Molecular Sequence Data
  • Plasmids / genetics*
  • Plasmids / isolation & purification
  • Vancomycin / pharmacology
  • Vancomycin Resistance

Substances

  • Anti-Bacterial Agents
  • DNA Transposable Elements
  • Vancomycin

Associated data

  • GENBANK/AB091473
  • GENBANK/AB105542
  • GENBANK/AB105543