Abstract
For the development of new anticonvulsive agents, GABAmimetics such as nipecotic acid, isonipecotic acid, gamma-aminobutyric acid (GABA), gamma-vinyl GABA (vigabatrin) and valproic acid were covalently coupled through an ester bond by a two-carbon linker chain as potential pro-drugs and evaluated for their anticonvulsive activities.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anticonvulsants / chemical synthesis*
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Anticonvulsants / pharmacology*
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Carbon / chemistry*
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Convulsants / administration & dosage
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Convulsants / adverse effects
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Convulsants / antagonists & inhibitors
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Dimerization*
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Drug Design*
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Electroshock / adverse effects
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Injections, Intraperitoneal
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Injections, Subcutaneous
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Isonipecotic Acids / administration & dosage
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Isonipecotic Acids / chemistry
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Isonipecotic Acids / pharmacokinetics
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Ligands
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Male
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Mice
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Mice, Inbred ICR
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Nipecotic Acids / administration & dosage
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Nipecotic Acids / chemistry
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Nipecotic Acids / pharmacokinetics
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Prodrugs / chemical synthesis*
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Prodrugs / metabolism
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Prodrugs / pharmacology*
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Seizures / chemically induced
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Seizures / drug therapy
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Seizures / physiopathology
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Valproic Acid / administration & dosage
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Valproic Acid / chemistry
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Valproic Acid / pharmacokinetics
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Vigabatrin / administration & dosage
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Vigabatrin / chemistry
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Vigabatrin / pharmacokinetics
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gamma-Aminobutyric Acid / administration & dosage
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gamma-Aminobutyric Acid / chemistry
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gamma-Aminobutyric Acid / pharmacokinetics
Substances
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Anticonvulsants
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Convulsants
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Isonipecotic Acids
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Ligands
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Nipecotic Acids
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Prodrugs
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gamma-Aminobutyric Acid
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Valproic Acid
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Carbon
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Vigabatrin