Imatinib induces mitochondria-dependent apoptosis of the Bcr-Abl-positive K562 cell line and its differentiation toward the erythroid lineage

MeSH terms

• Antineoplastic Agents / pharmacology*
• Apoptosis*
• Benzamides
• Cell Differentiation / drug effects
• Cell Lineage
• Enzyme Inhibitors / pharmacology
• Erythroid Precursor Cells / physiology
• Fusion Proteins, bcr-abl / analysis
• Fusion Proteins, bcr-abl / antagonists & inhibitors*
• Fusion Proteins, bcr-abl / metabolism
• Humans
• Imatinib Mesylate
• K562 Cells
• Leukemia, Myelogenous, Chronic, BCR-ABL Positive / genetics
• Leukemia, Myelogenous, Chronic, BCR-ABL Positive / metabolism*
• Leukemia, Myelogenous, Chronic, BCR-ABL Positive / pathology
• Mitochondria / drug effects*
• Models, Biological
• Oligonucleotide Array Sequence Analysis
• Phosphorylation
• Piperazines / pharmacology*
• Proto-Oncogene Proteins c-abl / metabolism
• Pyrimidines / pharmacology*
• Signal Transduction