Abstract
Resistance to linezolid among Enterococcus faecium and Enterococcus faecalis isolates has been reported in patients who receive a prolonged course of the drug. We report two cases of linezolid-resistant Enterococcus faecalis that occurred in patients who previously received linezolid for infections with vancomycin-resistant Enterococcus faecium. Both isolates had the G2576U mutation in the 23S rRNA previously reported in isolates of Enterococcus faecium. The number of gene copies mutated in the 23S rRNA correlated with the level of resistance.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetamides / administration & dosage
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Acetamides / pharmacology*
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Aged
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Base Sequence
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Cross Infection / diagnosis*
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Cross Infection / drug therapy
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Cross Infection / microbiology
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Dose-Response Relationship, Drug
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Drug Resistance, Microbial
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Enterococcus faecalis / drug effects*
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Enterococcus faecalis / genetics
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Genes, Bacterial / genetics
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Gram-Positive Bacterial Infections / diagnosis
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Gram-Positive Bacterial Infections / drug therapy*
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Hospitalization
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Humans
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Linezolid
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Male
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Microbial Sensitivity Tests
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Molecular Sequence Data
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Oxazolidinones / administration & dosage
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Oxazolidinones / pharmacology*
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Polymerase Chain Reaction
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Stroke / complications*
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Stroke / diagnosis
Substances
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Acetamides
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Oxazolidinones
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Linezolid