Abstract
Three isolates of zygomycetes were used to produce a disseminated infection in nonimmunocompromised mice. Against all zygomycete strains, amphotericin B significantly prolonged survival. Itraconazole was inactive against Rhizopus microsporus and Rhizopus oryzae but was partially active against Absidia corymbifera. Posaconazole had no beneficial effects against R. oryzae but showed partial activity against A. corymbifera. Posaconazole had a clear dose-response effect against R. microsporus.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Absidia / drug effects
-
Amphotericin B / pharmacology
-
Amphotericin B / therapeutic use
-
Animals
-
Antifungal Agents / pharmacology
-
Antifungal Agents / therapeutic use*
-
Brain / microbiology
-
Female
-
Itraconazole / pharmacology
-
Itraconazole / therapeutic use
-
Kidney / microbiology
-
Mice
-
Microbial Sensitivity Tests
-
Rhizopus / drug effects
-
Triazoles / pharmacology
-
Triazoles / therapeutic use*
-
Zygomycosis / drug therapy*
-
Zygomycosis / microbiology
Substances
-
Antifungal Agents
-
Triazoles
-
Itraconazole
-
posaconazole
-
Amphotericin B