Practical synthesis of sultams via sulfonamide dianion alkylation: application to the synthesis of chiral sultams

Org Lett. 2003 Oct 30;5(22):4175-7. doi: 10.1021/ol0356183.

Abstract

[reaction: see text]. A practical synthesis of sultams was developed via intramolecular sulfonamide dianion alkylation. This method has been applied toward the synthesis of chiral sultams, which are synthetically valuable as chiral auxiliaries.