Synthesis of oligonucleotide prodrugs bearing N-acetyl nucleobases

Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):1243-5. doi: 10.1081/NCN-120022846.

Abstract

N-Acetyl oligonucleotides and their prodrugs were synthesized on photolabile solid support. Tm studies showed a decrease of hydridization for N-acetyl A and G and an increase for N-acetyl C. In cells extract, acetyl groups were hydrolysed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetylation
  • Base Sequence
  • Hydrolysis
  • Indicators and Reagents
  • Nucleic Acid Conformation
  • Nucleosides / chemistry
  • Oligonucleotides / chemical synthesis*
  • Oligonucleotides / chemistry
  • Prodrugs / chemical synthesis*
  • Prodrugs / chemistry
  • Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

Substances

  • Indicators and Reagents
  • Nucleosides
  • Oligonucleotides
  • Prodrugs