Pheophorbide A-methyl ester, Acyl-CoA: cholesterol acyltransferase inhibitor from Diospyros kaki

Arch Pharm Res. 2003 Sep;26(9):716-8. doi: 10.1007/BF02976679.

Abstract

In the course of our search for Acyl-CoA: cholesterol acyltransferase (ACAT) inhibitors from natural sources, a new type of ACAT inhibitor was isolated from a methanol extract of Diospyros kaki. On the basis of spectral and structural evidence, the compound was identified as pheophorbide A-methyl ester. Pheophorbide A-methyl ester inhibited ACAT activity in a dose dependent manner with an IC50 value of 1.85 microg/mL.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acyl Coenzyme A / chemistry*
  • Acyl Coenzyme A / isolation & purification
  • Acyl Coenzyme A / pharmacokinetics
  • Animals
  • Chlorophyll / analogs & derivatives*
  • Chlorophyll / chemistry*
  • Chlorophyll / isolation & purification
  • Chlorophyll / pharmacokinetics
  • Chromatography, High Pressure Liquid / methods
  • Diospyros / chemistry*
  • Dose-Response Relationship, Drug
  • Drugs, Chinese Herbal
  • Gas Chromatography-Mass Spectrometry
  • Korea
  • Methanol
  • Methyl Ethers
  • Microsomes, Liver / enzymology
  • Molecular Structure
  • Plant Extracts / pharmacokinetics*
  • Plant Extracts / pharmacology*
  • Plant Leaves / chemistry*
  • Rats
  • Sterol O-Acyltransferase / antagonists & inhibitors*
  • Sterol O-Acyltransferase / isolation & purification*
  • Sterol O-Acyltransferase / pharmacokinetics

Substances

  • Acyl Coenzyme A
  • Drugs, Chinese Herbal
  • Methyl Ethers
  • Plant Extracts
  • Chlorophyll
  • Sterol O-Acyltransferase
  • pheophorbide a
  • Methanol